Sirtuin 1, stem cells, aging, and stem cell aging
نویسندگان
چکیده
منابع مشابه
Stem cell aging.
202 W E summarize here the fruitful discussion that occurred on a wide variety of topics during the session on stem cell aging. Somatic Stem Cell Aging Do stem cells age; and if they do, how can these changes be reliably identifi ed? Most attendees were of the view that a decline in the function of tissue-specifi c somatic stem cells is likely to play an important role in human aging. Results f...
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The stem cell theory of aging postulates that aging is the result of the failure of tissue specific stem cells to replenish tissues and to sustain tissue function. Stem cell functions decline with age, consistent with the degeneration and dysfunction of aging regenerative tissues. Stem cell dysfunction is associated with premature aging and evidence is emerging to suggest that stem cell manipul...
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Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In this review, we summarize current aspects ...
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Aging is defined broadly as the normal progressive process, consequently leading to growing vulnerability to disease and death. A major challenge lies in dissecting the underlying mechanisms of aging with conventional experiments due to the complex‐ ity of and multicontributions to the aging process, reflecting a need for investigation into it in various aspects. For this reason, the age proces...
متن کاملKlotho, stem cells, and aging
Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, s...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2008
ISSN: 1065-6251
DOI: 10.1097/moh.0b013e3283043819